Enteric Neuroscience Laboratory
Recent Publications
Roberts, R. R., Murphy, J. F., Young, H. M. & Bornstein, J. C. (2007). Development of colonic motility in the neonatal mouse-studies using spatiotemporal maps. Am J Physiol Gastrointest Liver Physiol 292, G930-938.
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Neal, K. B. & Bornstein, J. C. (2007). Mapping serotonin inputs to enteric neurons of the guinea pig small intestine. Neuroscience 145, 556-567.
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Gwynne, R. M. & Bornstein, J. C. (2007). Local inhibitory reflexes excited by mucosal application of nutrient amino acids in guinea pig jejunum. Am J Physiol Gastrointest Liver Physiol 292, G1660-1670.
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Gwynne, R. M. & Bornstein, J. C. (2007). Synaptic Transmission at Functionally Identified Synapses in the Enteric Nervous System: Roles for Both Ionotropic and Metabotropic Receptors. Curr. Neuropharmacol. 5, 1-17.
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Neal, K. B. & Bornstein, J. C. (2006). Serotonergic receptors in therapeutic approaches to gastrointestinal disorders. Curr Opin Pharmacol 6, 547-552.
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Kordasti, S., Sapnara, M., Thomas, E. A., Lindstrom, E., Forsman, M., Bornstein, J. C. & Sjovall, H. (2006). Effects of cholera toxin on the potential difference and motor responses induced by distension in the rat proximal small intestine in vivo. Am J Physiol Gastrointest Liver Physiol 290, G948-958.
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Davies, P. J., Thomas, E. A. & Bornstein, J. C. (2006). Different types of potassium channels underlie the long afterhyperpolarization in guinea-pig sympathetic and enteric neurons. Autonomic neuroscience : basic & clinical 124, 26-30.
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Bornstein, J. C. (2006). Intrinsic sensory neurons of mouse gut--toward a detailed knowledge of enteric neural circuitry across species. Focus on "characterization of myenteric sensory neurons in the mouse small intestine". J Neurophysiol 96, 973-974.
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Monro, R. L., Bornstein, J. C. & Bertrand, P. P. (2005). Slow excitatory post-synaptic potentials in myenteric AH neurons of the guinea-pig ileum are reduced by the 5-hydroxytrytamine7 receptor antagonist SB 269970. Neuroscience 134, 975-986.
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Chambers, J. D., Bornstein, J. C., Sjovall, H. & Thomas, E. A. (2005). Recurrent networks of submucous neurons controlling intestinal secretion: a modeling study. Am J Physiol Gastrointest Liver Physiol 288, G887-896.
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Thomas, E. A., Sjovall, H. & Bornstein, J. C. (2004). Computational model of the migrating motor complex of the small intestine
10.1152/ajpgi.00369.2003. Am J Physiol Gastrointest Liver Physiol 286, G564-572.
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Monro, R. L., Bertrand, P. P. & Bornstein, J. C. (2004). ATP participates in three excitatory postsynaptic potentials in the submucous plexus of the guinea pig ileum. J Physiol 556, 571-584.
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Johnson, P. J. & Bornstein, J. C. (2004). Neurokinin-1 and-3 receptor blockade inhibits slow excitatory synaptic transmission in myenteric neurons and reveals slow inhibitory input. Neuroscience 126, 137-147.
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Gwynne, R. M., Thomas, E. A., Goh, S. M., Sjövall, H. & Bornstein, J. C. (2004). Segmentation induced by intraluminal fatty acid in isolated guiea-pig duodenum and jejunum. J Physiol 556, 557-569.
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Bornstein, J. C., Costa, M. & Grider, J. R. (2004). Enteric motor and interneuronal circuits controlling motility. Neurogastroenterol Motil 16, 34-38.
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Bian, X.-C., Heffer, L. F., Gwynne, R. M., Bornstein, J. C. & Bertrand, P. P. (2004). Synaptic transmission in simple motility reflex pathways excited by distension in guinea pig distal colon
10.1152/ajpgi.00039.2004. Am J Physiol Gastrointest Liver Physiol 287, G1017-1027.
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Anderson, R. B., Enomoto, H., Bornstein, J. C. & Young, H. M. (2004). The enteric nervous system is not essential for the propulsion of gut contents in fetal mice. Gut, 1546.
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Thomas, E. A. & Bornstein, J. C. (2003). Inhibitory cotransmission or after-hyperpolarizing potentials can regulate firing in recurrent networks with excitatory metabotropic transmission. Neuroscience 120, 333-351.
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Stanton, M. P., Hengel, P. T., Southwell, B. R., Chow, C. W., Keck, J., Hutson, J. M. & Bornstein, J. C. (2003). Cholinergic transmission to colonic circular muscle of children with slow-transit constipation is unimpaired, but transmission via NK2 receptors is lacking. Neurogastroenterology & Motility 15, 669-678.
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Bian, X. C., Bornstein, J. C. & Bertrand, P. P. (2003). Nicotinic transmission at functionally distinct synapses in descending reflex pathways of the rat colon. Neurogastroenterol Motil 15, 161-171.
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Thornton, P. D. J. & Bornstein, J. C. (2002). Slow excitatory synaptic potentials evoked by distension in myenteric descending interneurons of guinea-pig ileum. J Physiol 539, 589-602.
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Monro, R. L., Bertrand, P. P. & Bornstein, J. C. (2002). ATP and 5-HT are the principal neurotransmitters in the descending excitatory reflex pathway of the guinea-pig ileum. Neurogastroenterol Motil 14, 255-264.
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Bertrand, P. P. & Bornstein, J. C. (2002). ATP as a putative sensory mediator: Activation of intrinsic sensory neurons of the myenteric plexus via P2X receptors. J Neurosci 22, 4767-4775.
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Bornstein JC, Furness JB, Kunze WA and Bertrand PP (2002) Enteric Reflexes that Influence Motility. Innervation of the Gastrointestinal Tract. M. Costa and S. H. Brookes: 1-55.
Google Book Entry
Small, D. H., Mok, S. S. & Bornstein, J. C. (2001). Alzheimer's disease and AP toxicity: from top to bottom. Nat Rev Neurosci 2, 595-598.
Thomas, E. A., Bertrand, P. P. & Bornstein, J. C. (2000). A computer simulation of recurrent, excitatory networks of sensory neurons of the gut in guinea-pig. Neurosci Lett 287, 137-140.
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Furness, J. B., Clerc, N., Lomax, A. E. G., Bornstein, J. C. & Kunze, W. A. A. (2000). Shapes and projections of tertiary plexus neurons of the guinea-pig small intestine. Cell and Tissue Research 300, 383-387.
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Bian, X. C., Bertrand, P. P., Furness, J. B. & Bornstein, J. C. (2000). Evidence for functional NK1-tachykinin receptors on motor neurones supplying the circular muscle of guinea-pig small and large intestine. Neurogastroenterol Motil 12, 307-315.
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Bian, X., Bertrand, P. P. & Bornstein, J. C. (2000). Descending inhibitory reflexes involve P2X receptor-mediated transmission from interneurons to motor neurons in guinea-pig ileum. J Physiol 528, 551-560.
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Bertrand, P. P., Thomas, E. A., Kunze, W. A. A. & Bornstein, J. C. (2000). A simple mathematical model of second-messenger mediated slow excitatory postsynaptic potentials. J Comput Neurosci 8, 127-142.
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Bertrand, P. P., Kunze, W. A. A., Furness, J. B. & Bornstein, J. C. (2000). The terminals of myenteric intrinsic primary afferent neurons of the guinea pig ileum are excited by 5-HT acting at 5-HT3 receptors. Neuroscience 101, 459-469.
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