Profile
PhD (2002) “A comparison of the pharmacological activity of the venoms of three Australian fish”, Dept of Pharmacology, Monash University.
Postdoctoral training (2002-2004) Calcium Signalling Laboratory, Dept of Pharmacology, University of Cambridge, UK.
Postdoctoral training (2004-2006) Vascular Biology Centre, Medical College of Georgia, USA.
Teaching
- 316-308 Physiology of Muscle and Exercise (Lecturer)
- 516-307 Research Topics in Physiology (Supervisor)
Service to the University, discipline
or community and recent presentations
Member of the Australian Physiological Society (AuPS)
Member of the American Physiological Society (APS)
Member of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT)
Deputy Departmental Academic Liaison Officer (Publications)
Research
Profile, Interests and Recent Publications
I am interested in the effects that both ageing and disease states such as dystrophy have on muscles, particularly the intracellular signalling and cardiovascular events that underlie these processes.
Recent Research Presentations:
Church JE, Gehrig SM, McConell GK, Lynch GS. Nitric oxide and skeletal muscle regeneration in mice after injury – the role of muscular nNOS. Annual Scientific Meeting of the AuPS, 2008.
Recent Publications:
White PJ, Anastasopoulos F, Church JE, Boyd BJ, Hickey P, Sze Tu L, Burns P, Lew AM, Heath WR, Davey GM, Pouton CW. Generic construction of single component nanoparticles that elicit humoral and cellular immune responses without the need for adjuvants. Vaccine 2008, 26:6824-6831.
Tovey SC, Dedos SG, Taylor EJA, Church JE, Taylor CW. Selective coupling of Type 6 Adenylyl Cyclase with Type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP. J Cell Biol. 2008; 183:297-311.
Jagnandan D, Church JE, Banfi B, Stuehr DJ, Marrero MB, Fulton DJ. Novel mechanism of activation of NADPH oxidase 5 – calcium sensitization via phosphorylation. J Biol Chem. 2007; 282:6494-6507.
Zhang Q, Church JE, Jagnandan D, Catravas JD, Sessa WC, Fulton D. Functional relevance of Golgi- and plasma membrane-localized endothelial NO synthase in reconstituted endothelial cells. Arterioscler Thromb Vasc Biol. 2006; 26: 1015-1021.
Church JE, Fulton D. Differences in eNOS activity because of subcellular localization are dictated by phosphorylation state rather than the local calcium environment. J Biol Chem. 2006; 281: 1477-1488.
Research
Funding
Research Funding:
Rebecca L Cooper Foundation, Ltd -
Investigating the potential for erectile dysfunction drugs to enhance the repair of injured skeletal muscles in the elderly (GS Lynch & JE Church)
University of Melbourne Early Career Researcher Program - Manipulating the Notch signalling pathway to treat Muscular Dystrophy (JE Church)
Supervisor
Gordon Lynch
Currently
Supervised Staff/Students
Marc Nicolas
