Profile
PhD (2002-2005): School of Human Movement, Recreation and Performance, Victoria University. “Exercise, electrical stimulation and ionic effects on Na+,K+-ATPase isoform gene and protein expression in mammalian skeletal muscle”
Postdoctoral training (2005-2007): Institute of Physiology and Biophysics, University of Aarhus, Århus; Denmark
Teaching
316-308 Physiology of Muscle and Exercise (Lecturer)
Service to the University, discipline
or community and recent presentations
Council member of the Australian Physiological Society (2008-2010)
Organising committee member of MyoNak 2009 Conference
Member of the following societies:
• Australian Physiological Society
• American Physiological Society
• Australian Association of Gerontology
• Potassium, Sodium and the Function of the Heart and Skeletal Muscle: International Research Interest Group (founding member).
Research
Profile, Interests and Recent Publications
I am interested in the physiological mechanisms contributing to skeletal muscle wasting and weakness in cancer, ageing and muscular dystrophy, and designing therapeutic strategies to ameliorate muscle wasting in these conditions.
Recent Publications:
Ryall JG, Schertzer JD, Murphy KT, Allen AM and Lynch GS. Chronic β2-adrenoceptor stimulation impairs cardiac relaxation via reduced SR Ca2+-ATPase protein and activity. Am J Physiol 294: H2587-95, 2008.
Murphy KT, Nielsen OB and Clausen T. Analysis of exercise-induced Na+,K+ exchange in rat skeletal muscle in-vivo. Exp Physiol 93: 1249-1262, 2008.
Murphy KT, Medved I, Brown MJ, Cameron-Smith D and McKenna MJ. Antioxidant treatment with N-acetylcysteine regulates mammalian skeletal muscle Na+,K+-pump gene expression during repeated contractions. Exp Pysiol 93: 1239-1248, 2008.
Murphy KT and Clausen T. The importance of limitations in aerobic metabolism, glycolysis and membrane excitability for the development of high-frequency fatigue in isolated rat soleus muscle. Am J Physiol 292: R2001-2011, 2007.
Murphy KT, Bundgaard H and Clausen T. 3-adrenoceptor agonist stimulation of the Na+,K+-pump in rat skeletal muscle is mediated by 2- rather than 3-adrenoceptors. Br J Pharm 149: 635-646, 2006.
Research
Funding
Research Funding:
NHMRC – Peter Doherty Biomedical Training Fellowship
University of Melbourne Early Career Researcher Program
RM Gibson Research Fund Award
Recent Research Presentations:
Murphy KT, Ryall JG, Koopman R and Lynch GS. Age-related alterations in transforming growth factor-β (TGF-β) signalling in rat skeletal muscle: implications for sarcopenia. Annual Meeting of the Australian Physiological Society, 2008.
Supervisor
Gordon Lynch
