PhD (2002-2005): “Exercise, electrical stimulation and ionic effects on Na+,K+-ATPase isoform gene and protein expression in mammalian skeletal muscle”
School of Human Movement, Recreation and Performance, Victoria University.
Postdoctoral training (2005-2007): Institute of Physiology and Biophysics, University of Aarhus, Århus; Denmark
NHMRC Peter Doherty Fellowship (2008-2012): Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne.
NHMRC Career Development Fellowship (2012-2016): Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne.
316-308 Physiology of Muscle and Exercise (Lecturer)
Service to the University, discipline
or community and recent presentations
Category B member of The University of Melbourne Animal Ethics Committee (2012-)
- Australian Physiological Society
- Australian Society for Medical Research
- Society on Cachexia and Wasting Disorders
- American Physiological Society
Active participant in Scientists in Schools program
Assessor of project grant applications for the National Health and Medical Research Council (NHMRC), the Auckland Medical Research Foundation and The Wellcome Trust.
Reviewer of manuscripts for scientific journals, including Pflügers Archives, PLoS One, American Journal of Physiology, Apoptosis, Journal of Applied Physiology, Acta Physiologica, European Journal of Cell Biology, Nutrition, Metabolism & Cardiovascular Diseases and the Journal of Neurology and Pulmonary Pharmacology and Therapeutics.
Profile, Interests and Recent Publications
Cancer cachexia is the skeletal muscle wasting and weakness associated with many forms of cancer. Cancer cachexia impairs functional independence, leads to an overall reduction in patient quality of life, and accounts for >20% of cancer-related deaths. My research investigates the physiological mechanisms contributing to cancer cachexia and examines the therapeutic potential of strategies designed to ameliorate this devastating disease.
Current research funding:
NHMRC Career Development Fellowship (2012-2016)
Recent research presentations:
Murphy KT. Renin-Angiotensin System in Muscle. Gage Muscle Conference, 2012. Canberra.
Murphy KT. Antibody-directed myostatin inhibition attenuates atrophy and loss of muscle function in murine models of skeletal muscle wasting. TGF-β down under Meeting, 2011. Melbourne.
Murphy KT, Chee A, Allen AM and Lynch GS. Inhibition of the renin-angiotensin system enhances whole body and skeletal muscle function in healthy and tumour-bearing mice. Joint Meeting of the Australian Physiologycal Society and Australian Society for Biophysics, 2011. Adelaide.
Murphy KT, Ham DJ, Church JE, Naim T, Trieu J, Williams DA and Lynch GS. Parvalbumin gene transfer impairs skeletal muscle contractility in old mice. Human Gene Therapy Epub 30/3/12 doi:10.1089/hum.2011.210.
Murphy KT, Chee A, Trieu J, Naim T and Lynch GS. Importance of functional and metabolic impairments in the characterization of the C-26 murine model of cancer cachexia. Disease Models & Mechanisms Feb 16 In Press, 2012.
Murphy KT and Lynch GS. Editorial update on emerging drugs for cancer cachexia. Expert Opinion on Emerging Drugs 17: 5-9, 2012.
Murphy KT, Chee A, Gleeson BG, Naim T, Swiderski K, Koopman R and Lynch GS. Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice. American Journal of Physiology 301: R716-R726, 2011.
J H Huang